The Defenders is a superhero team in the Marvel Universe. It started when the Hulk was out of control in a city, so Namor and Doctor Strange teamed up against him to defend the city, and with time Hulk already under control and the Silver Surfer joined them to form a group of superheroes who with the time ended up gaining more members. (Valkyrie, Luke Cage, Iron First, Daredevil, etc.)
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The Defenders are formed in The Super Hero Squad Show episode "Invader From the Dark Dimension". When Baron Mordo possesses Iron Man, Wolverine, Falcon, and Redwing, a new group is formed by Doctor Strange, Valkyrie, Hulk, Thor, and Silver Surfer to stop Mordo.
An eight episode Defenders miniseries aired on Netflix during the summer of 2017. It was set in the Marvel Cinematic Universe and served as a culmination of the storylines from Daredevil, Jessica Jones, Luke Cage and Iron Fist, with Charlie Cox, Krysten Ritter, Mike Colter, and Finn Jones reprising their roles. The show revolved around the team organizing to fight an enemy that threatens them all: The Hand.